Imhof H G, Gütling E, Rüttner B, Dolder E, Zollinger A, Walser H
Neurochirurgische Klinik, Universitätsspitals Zürich.
Aktuelle Traumatol. 1993 Feb;23(1):7-13.
By stimulation of the median nerve at the wrist we recorded the somatosensory evoked potentials (SEP) at several points between the midpoint of the clavicle and the scalp, overlying the area of sensorimotor cortex. The SEP of each side were graded (bilaterally normal SEP's: grade-1/1, pathological SEP's grade-2/1 to grade-4/4). The aim of these recordings is to judge the probability of survival in adult comatous patients in the early phase after a head injury. Our retrospective analysis of these recordings in 108 patients (collective 1988/89) shows a significant correlation of the SEP with the Glasgow Coma Scale score (GCS) (GCS > 8/SEP grade-3 or grade-4: p < 0.005) and the pupillary function (pupillary function disturbed uni- or bilaterally/SEP grade-3 or grade-4: p < 0.0005), being less pronounced with the intracranial pressure (ICP) too. In patients with lack of the component N20 death or vegetative outcome is significantly more frequent than if this component is present (p < 0.005). All the 7 patients without recognisable bilateral component N20 (SEP grade-4/4) died as a consequence of the initial brain injury. 7 out of 9 patients with unilateral lack of the component N20 combined with diminished amplitude ratio and delayed central conduction time (CCT) contralaterally (SEP grade-4/3) died or survived in a vegetative condition; none of them became independent. If the results of the analysis of the patient collective 1988/89 were applied to the patients of 1990 (n = 67) a good correlation between SEP and outcome was confirmed.(ABSTRACT TRUNCATED AT 250 WORDS)
通过刺激手腕部的正中神经,我们在锁骨中点与头皮之间的几个点记录体感诱发电位(SEP),这些点位于感觉运动皮层区域上方。对每一侧的SEP进行分级(双侧SEP正常:1/1级,病理性SEP:2/1级至4/4级)。这些记录的目的是判断成年昏迷患者在头部受伤后早期的存活概率。我们对108例患者(1988/89年的病例组)的这些记录进行回顾性分析,结果显示SEP与格拉斯哥昏迷量表评分(GCS)(GCS>8/SEP 3级或4级:p<0.005)以及瞳孔功能(单侧或双侧瞳孔功能障碍/SEP 3级或4级:p<0.0005)之间存在显著相关性,与颅内压(ICP)的相关性则较弱。在缺乏N20成分的患者中,死亡或植物人状态的发生率明显高于存在该成分的患者(p<0.005)。所有7例未检测到双侧N20成分(SEP 4/4级)的患者均因初始脑损伤而死亡。9例单侧缺乏N20成分且对侧波幅比降低和中枢传导时间(CCT)延迟(SEP 4/3级)的患者中,7例死亡或处于植物人状态存活;无一例能够独立生活。如果将1988/89年病例组的分析结果应用于1990年的患者(n = 67),则证实SEP与预后之间具有良好的相关性。(摘要截短至250字)