在不同品系的叙利亚仓鼠（金仓鼠）中，血浆脂蛋白、胆汁脂质和胆汁酸谱存在差异。
Plasma lipoproteins, biliary lipids and bile acid profile differ in various strains of Syrian hamsters Mesocricetus auratus.
作者信息
Trautwein E A, Liang J, Hayes K C
机构信息
Foster Biomedical Research Laboratory, Brandeis University, Waltham, MA 02254.
出版信息
Comp Biochem Physiol Comp Physiol. 1993 Apr;104(4):829-35. doi: 10.1016/0300-9629(93)90162-w.
PMID:8097989
Abstract
- Plasma and biliary lipids were assessed in four strains of Syrian hamsters [Charles River Lakeview, (CHR), Biobreeder F1B (BIO), Harlan Sprague-Dawley (HAR) and Sasco (SAS)] fed a cholesterol-free diet. 2. Plasma cholesterol differed with SAS > CHR > HAR > BIO. 3. BIO Hamsters had the lowest HDL and highest VLDL + LDL/HDL ratio, but their biliary secretion of bile acids, phospholipids and cholesterol was 50% lower than other hamsters. 4. Chenodeoxycholate was highest in CHR and the cholate:cheno ratio depressed in CHR hamsters. 5. CHR hamsters had the highest lithogenic index and cholesterol-saturated bile.
摘要
- 对四株叙利亚仓鼠[查尔斯河湖景株（CHR）、生物育种F1B株（BIO）、哈兰斯普拉格-道利株（HAR）和萨斯科株（SAS）]喂食无胆固醇饮食后，对其血浆和胆汁脂质进行了评估。2. 血浆胆固醇水平存在差异，顺序为SAS > CHR > HAR > BIO。3. BIO仓鼠的高密度脂蛋白（HDL）最低，极低密度脂蛋白（VLDL）+低密度脂蛋白（LDL）/HDL比值最高，但其胆汁酸、磷脂和胆固醇的胆汁分泌量比其他仓鼠低50%。4. 鹅去氧胆酸盐在CHR株中含量最高，CHR仓鼠中胆酸盐与鹅去氧胆酸盐的比例降低。5. CHR仓鼠具有最高的致石指数和胆固醇饱和胆汁。
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