Lampeter E F, Homberg M, Quabeck K, Schaefer U W, Wernet P, Bertrams J, Grosse-Wilde H, Gries F A, Kolb H
Diabetes Research Institute, Düsseldorf, Germany.
Lancet. 1993 May 15;341(8855):1243-4. doi: 10.1016/0140-6736(93)91148-f.
Insulin-dependent diabetes was observed in a woman, aged 29, 4 years after transplantation of bone marrow from her HLA-identical brother with insulin-dependent diabetes. Both had classic symptoms and insulin dependency from onset. At diagnosis of diabetes the recipient was positive for high-titre islet cell antibodies (ICA) whereas she had been ICA negative before transplantation. Chromosomal analyses verified that all circulating leucocytes were of male donor type. These findings suggest transfer of insulin-dependent diabetes by bone marrow cells and confirm the immune nature of the disease.
在一名29岁女性中观察到胰岛素依赖型糖尿病，这是在她接受来自患有胰岛素依赖型糖尿病的 HLA 同型兄弟的骨髓移植4年后出现的。两人从发病起都有典型症状且依赖胰岛素。在诊断糖尿病时，受体的高滴度胰岛细胞抗体（ICA）呈阳性，而移植前她的 ICA 为阴性。染色体分析证实所有循环白细胞均为男性供体类型。这些发现提示胰岛素依赖型糖尿病可通过骨髓细胞转移，并证实了该疾病的免疫性质。
