Bulfone A, Kim H J, Puelles L, Porteus M H, Grippo J F, Rubenstein J L
Department of Psychiatry, UCSF 94143.
Mech Dev. 1993 Mar;40(3):129-40. doi: 10.1016/0925-4773(93)90071-5.
The pattern of RNA expression of the murine Dlx-2 (Tes-1) homeobox gene is described in embryos ranging in age from E8.5 through E11.5. Dlx-2 is a vertebrate homologue of the Drosophila Distal-less (Dll) gene. Dll expression in the Drosophila embryo is principally limited to the primordia of the brain, head and limbs. Dlx-2 is also expressed principally in the primordia of the forebrain, head and limbs. Within these regions it is expressed in spatially restricted domains. These include two discontinuous regions of the forebrain (basal telencephalon and ventral diencephalon), the branchial arches, facial ectoderm, cranial ganglia and limb ectoderm. Several mouse and human disorders have phenotypes which potentially are the result of mutations in the Dlx genes.
本文描述了小鼠Dlx-2（Tes-1）同源框基因在胚胎发育E8.5至E11.5阶段的RNA表达模式。Dlx-2是果蝇Distal-less（Dll）基因的脊椎动物同源物。Dll在果蝇胚胎中的表达主要局限于脑、头部和肢体的原基。Dlx-2也主要在前脑、头部和肢体的原基中表达。在这些区域内，它在空间受限的区域表达。这些区域包括前脑的两个不连续区域（基底端脑和腹侧间脑）、鳃弓、面部外胚层、颅神经节和肢体外胚层。几种小鼠和人类疾病的表型可能是Dlx基因突变的结果。
