Lancet. 1993 May 29;341(8857):1359-62.
Gastric infection with Helicobacter pylori seems to be a risk factor for gastric cancer. We have conducted a multicentre epidemiological study to investigate this relation further. Our study was designed to look at the relation between the prevalence of H pylori infection and gastric cancer rates in 17 populations from 13 countries, chosen to reflect the global range of gastric cancer incidence. In each centre, about 50 males and 50 females in each of the two age groups 25-34 years and 55-64 years were selected at random from the local population and provided blood samples. Serum samples were assayed for the presence of IgG antibodies to H pylori in a single laboratory. Prevalence rates of H pylori seropositivity were related to local gastric cancer incidence and mortality rates using linear regression. There was a statistically significant relation between the prevalence of seropositivity and cumulative rates (0-74 years) for both gastric cancer incidence and mortality with regression coefficients of 2.68 (p = 0.001) and 1.79 (p = 0.002), respectively. Our findings are consistent with an approximately six-fold increased risk of gastric cancer in populations with 100% H pylori infection compared with populations that have no infection.
幽门螺杆菌胃部感染似乎是胃癌的一个风险因素。我们开展了一项多中心流行病学研究以进一步调查这种关系。我们的研究旨在观察来自13个国家的17个人群中幽门螺杆菌感染率与胃癌发病率之间的关系，这些人群的选择是为了反映全球胃癌发病率的范围。在每个中心，从当地人群中随机选取25 - 34岁和55 - 64岁这两个年龄组中的各约50名男性和50名女性，并采集血样。血清样本在单个实验室中检测幽门螺杆菌IgG抗体的存在情况。使用线性回归分析幽门螺杆菌血清阳性率与当地胃癌发病率和死亡率之间的关系。血清阳性率与胃癌发病率和死亡率的累积率（0 - 74岁）之间存在统计学上的显著关系，回归系数分别为2.68（p = 0.001）和1.79（p = 0.002）。我们的研究结果表明，与未感染人群相比，幽门螺杆菌感染率达100%的人群患胃癌的风险增加了约6倍。
