Faujo Nintewoue Ghislaine Florice, Tali Nguefak Lionel Danny, Ngatcha Ghislaine, Tagni Sartre Michele, Talla Paul, Menzy Moungo-Ndjole Carole Marlyse, Kouitcheu Mabeku Laure Brigitte
Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of Science University of Dschang Dschang Cameroon.
Regional Hospital Bafoussam Bafoussam Cameroon.
JGH Open. 2023 Sep 5;7(9):618-628. doi: 10.1002/jgh3.12958. eCollection 2023 Sep.
There is an intimate relationship between oxidative stress and inflammation. infection leads to gastritis in almost all the hosts. So, we hypothesize that gastritis in infection may be described as the accumulation of continuous oxidative damage.
The study was conducted from October 2020 to October 2021 at three reference health facilities in Cameroon A total of 266 participants (131 males and 135 females) ranging from 15 to 88 years old with 48.28 ± 17.29 years as mean age were enrolled. Each participant gave a written informed consent and ethical committees approved the protocol. Biopsies samples were collected for detection using histological examination and rapid urease test. Malondialdehyde (MDA) and glutathione (GSH) content, and catalase (CAT) and superoxide dismutase (SOD) activities were evaluated in serum as biomarkers of oxidative stress.
was detected in 71.80% of our sample population. Low income level was associated with higher GSH level ( = 0.0249) and having family history of gastric cancer to higher SOD activity ( = 0.0156). A significant higher MDA content ( < 0.0001) and SOD activity ( = 0.0235) was recorded among infected individuals compared with noninfected ones. A significantly higher MDA content and SOD activity was recorded among smokers ( = 0.0461) and participants older than 50 years old ( = 0.0491) with positivity.
Our findings showed that infection is associated with overproduction of reactive oxygen species and oxidative stress. The presence of this pathogen in elderly individuals or in smokers increased their risk for oxidative stress.
氧化应激与炎症之间存在密切关系。感染几乎会导致所有宿主患胃炎。因此，我们假设感染引起的胃炎可被描述为持续氧化损伤的积累。
该研究于2020年10月至2021年10月在喀麦隆的三个参考卫生机构进行。共招募了266名参与者（131名男性和135名女性），年龄在15至88岁之间，平均年龄为48.28±17.29岁。每位参与者均签署了书面知情同意书，且研究方案获得了伦理委员会的批准。采集活检样本，通过组织学检查和快速尿素酶试验进行检测。评估血清中丙二醛（MDA）和谷胱甘肽（GSH）含量以及过氧化氢酶（CAT）和超氧化物歧化酶（SOD）活性，作为氧化应激的生物标志物。
在我们71.80%的样本人群中检测到（此处原文缺失具体检测内容）。低收入水平与较高的GSH水平相关（P = 0.0249），有胃癌家族史与较高的SOD活性相关（P = 0.0156）。与未感染个体相比，感染个体的MDA含量（P < 0.0001）和SOD活性（P = 0.0235）显著更高。在（此处原文缺失具体相关因素）阳性的吸烟者（P = 0.0461）和50岁以上参与者（P = 0.0491）中，MDA含量和SOD活性也显著更高。
我们的研究结果表明，（此处原文缺失具体感染因素）感染与活性氧的过度产生和氧化应激有关。这种病原体在老年人或吸烟者中的存在增加了他们氧化应激的风险。
