Jackson D, Vanderschueren-Lodeweyckx M, Grant D B
Arch Dis Child. 1975 Jul;50(7):522-5. doi: 10.1136/adc.50.7.522.
Serum thyrotrophin (TSH) was estimated by double-antibody radioimmunoassay in 200 children aged 2 months to 16 years with normal thyroid function. There was no apparent variation in TSH with age or sex and only 4 children had TSH levels greater than 5 muU/ml. High TSH values were obtained in 9 children with primary hypothyroidism, in 3 children with thyroiditis, and in one girl with a lingual thyroid. Moderately raised TSH was found in 3 girls with thyroiditis, 2 brothers with goitres due to enzyme defect, and a girl with an ectopic thyroid. In one girl with a defect of iodine organification and in 3 boys with thyroxine binding globulin deficiency the TSH levels were normal despite very low serum thyroxine values. Serum TSH was also estimated in 20 children during treatment for primary hypothyroidism. 3 of these children showed slightly raised TSH levels despite apparently adequate replacement therapy with L-thyroxine. One girl showed a very high TSH level 3 weeks after treatment had been temporarily withdrawn.
采用双抗体放射免疫分析法对200名年龄在2个月至16岁、甲状腺功能正常的儿童进行血清促甲状腺激素（TSH）测定。TSH水平在不同年龄和性别的儿童中无明显差异，仅有4名儿童的TSH水平高于5 μU/ml。9名原发性甲状腺功能减退症患儿、3名甲状腺炎患儿及1名患有舌甲状腺的女孩TSH值较高。3名甲状腺炎女孩、2名因酶缺陷导致甲状腺肿大的兄弟及1名患有异位甲状腺的女孩TSH中度升高。1名碘有机化缺陷的女孩及3名甲状腺素结合球蛋白缺乏的男孩，尽管血清甲状腺素值极低，但TSH水平正常。对20名原发性甲状腺功能减退症患儿进行治疗期间也测定了血清TSH。其中3名患儿尽管接受了明显足够的左甲状腺素替代治疗，但TSH水平仍略有升高。1名女孩在治疗暂时中断3周后TSH水平非常高。
