使用单基因座探针技术对嵌合双胞胎、真两性畸形和男性假两性畸形进行DNA分析。
DNA profiles of chimeric twins, TS and MR using the single-locus-probe technique.
作者信息
Hansen H E, Søndervang A
机构信息
Institute of Forensic Genetics, University of Copenhagen, Denmark.
出版信息
Hum Hered. 1993 Mar-Apr;43(2):98-102. doi: 10.1159/000154124.
A pair of blood-group-chimeric twins, TS and MR and their family have been investigated with the single-locus-probe DNA technique for restriction fragment length polymorphism in five variable-numbers-of-tandem-repeat systems. An admixture of DNA from the other twin could be demonstrated in both twins, leading to a possible false-genotype determination in at least one system. Chimerism is a potential pitfall in DNA investigations with single-locus probes in forensic genetics.
对一对血型嵌合双胞胎TS和MR及其家人，采用单基因座探针DNA技术，对五个串联重复序列可变数目的系统进行了限制性片段长度多态性研究。在两个双胞胎中均发现了来自另一个双胞胎的DNA混合情况，这可能导致至少在一个系统中出现假基因型判定。嵌合现象是法医遗传学中使用单基因座探针进行DNA检测时的一个潜在陷阱。
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