Udén P, Aspegren K, Balldin G, Garne J P, Larsson S A
Department of Surgery, Malmö Allmänna sjukhus, Lund University, Sweden.
Eur J Surg. 1993 May;159(5):263-5.
To find out if fibrin adhesive glue applied locally would reduce the incidence of seroma after modified radical mastectomy for breast cancer.
Prospective randomised study.
City hospital, Sweden.
68 women undergoing modified radical mastectomy with axillary clearance for breast cancer.
Amount of postoperative drainage, number of seromas aspirated volumes; length of hospital stay, influence of surgeon operating.
Seromas developed in a total of 40/68 patients (59%), 23/36 in the fibrin adhesive group (64%) and 17/32 in the control group (53%); p = 0.5 (95% confidence interval of the difference--0.13 to 0.34). There were no significant differences in the volume of aspirations or in hospital stay. The skill of the surgeon influenced the incidence of seromas, but the differences were not significant (p = 0.5).
Local application of a fibrin adhesive glue has no effect on the incidence of seroma formation after modified radical mastectomy.
探究局部应用纤维蛋白黏合剂是否会降低乳腺癌改良根治术后血清肿的发生率。
前瞻性随机研究。
瑞典市立医院。
68例行乳腺癌改良根治术并腋窝清扫术的女性患者。
术后引流量、抽吸血清肿的次数及量；住院时间、手术医生的影响。
68例患者中共有40例（59%）发生血清肿，纤维蛋白黏合剂组36例中有23例（64%），对照组32例中有17例（53%）；p = 0.5（差异的95%置信区间为 -0.13至0.34）。抽吸量或住院时间无显著差异。手术医生的技术影响血清肿的发生率，但差异不显著（p = 0.5）。
局部应用纤维蛋白黏合剂对乳腺癌改良根治术后血清肿的形成发生率无影响。
