Wong C T, Tsoi W F, Saha N
Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore.
Schizophr Res. 1996 Nov 15;22(2):165-71. doi: 10.1016/s0920-9964(96)00037-0.
Changes in the concentration of some serum acute phase proteins (alpha 1-antitrypsin, alpha 2-macroglobulin, complement C3, haptoglobin, ceruloplasmin, transferrin, albumin and hemopexin), thyroxine-binding globulin, retinol-binding globulin, plasminogen and Gc-globulin are reported in two separate series of Chinese, male schizophrenic patients and healthy controls. In the first series, 41 healthy blood donors and 98 schizophrenic patients in different stages of the disease were investigated. The second series consists of a random sample of 50 acutely ill schizophrenic patients and a second group of healthy subjects. The concentrations of these serum proteins were measured by rocket immunoelectrophoresis in agarose gel. Increased levels of serum alpha 1-antitrypsin, alpha 2-macroglobulin, haptoglobin, ceruloplasmin, and thyroxine-binding globulin were observed in both series of patients when compared to their respective controls. Albumin, transferrin and retinol-binding protein levels were reduced in patients in both series. Hemopexin levels were increased only in the acutely ill patients while complement C3 was decreased in the chronically ill patients. No changes were observed in the Gc-globulin levels of all groups of patients. With the exception of complement C3, the changes observed in the levels of these serum proteins were appropriate for that of an acute phase response.
在两组不同的中国男性精神分裂症患者和健康对照者中，报告了一些血清急性期蛋白（α1 - 抗胰蛋白酶、α2 - 巨球蛋白、补体C3、触珠蛋白、铜蓝蛋白、转铁蛋白、白蛋白和血红素结合蛋白）、甲状腺素结合球蛋白、视黄醇结合球蛋白、纤溶酶原和Gc - 球蛋白浓度的变化。在第一组中，研究了41名健康献血者和98名处于疾病不同阶段的精神分裂症患者。第二组由50名急性病精神分裂症患者的随机样本和第二组健康受试者组成。这些血清蛋白的浓度通过琼脂糖凝胶火箭免疫电泳法进行测量。与各自的对照组相比，在两组患者中均观察到血清α1 - 抗胰蛋白酶、α2 - 巨球蛋白、触珠蛋白、铜蓝蛋白和甲状腺素结合球蛋白水平升高。两组患者的白蛋白、转铁蛋白和视黄醇结合蛋白水平均降低。血红素结合蛋白水平仅在急性病患者中升高，而补体C3在慢性病患者中降低。所有患者组的Gc - 球蛋白水平均未观察到变化。除补体C3外，这些血清蛋白水平的变化符合急性期反应的变化。
