Bach J F
Dept of Clinical Immunology, Hôpital Necker, Paris, France.
Immunol Today. 1993 Jun;14(6):322-6. doi: 10.1016/0167-5699(93)90053-N.
Cyclosporin A, corticosteroids and cyclophosphamide show a remarkable efficacy in a large number of autoimmune diseases. However, their effect is dependent on continuous drug administration with potential risks of drug toxicity and over immunosuppression. Results recently obtained in animal models, particularly with anti-CD3 and anti-CD4 monoclonal antibodies, indicate that reestablishment of tolerance to self antigens is a feasible goal.
环孢素A、皮质类固醇和环磷酰胺在大量自身免疫性疾病中显示出显著疗效。然而，它们的效果依赖于持续给药，存在药物毒性和免疫过度抑制的潜在风险。最近在动物模型中获得的结果，特别是使用抗CD3和抗CD4单克隆抗体的结果表明，重建对自身抗原的耐受性是一个可行的目标。
