Liu Y M
Department of Respiratory Medicine, General Hospital of Beijing Military Command.
Zhonghua Jie He He Hu Xi Za Zhi. 1993 Feb;16(1):11-4, 61.
The Bmax of value of beta receptors in membrane prepared from lung tissue of ARDS rats were remarkably decreased (P < 0.01) after 4h of injury (307 +/- 55fmol/mg protein) and 6h (240 +/- 66fmol/mg protein) as compared with that of control (490 +/- 61fmol/mg protein), whereas that of the alpha 1 receptors was increased markedly (P < 0.01) after 4h of injury (127 +/- 12fmol/mg protein) as compared with that of the control (83 +/- 7fmol/mg protein). In anisodamine treatment group, the Bmax of beta receptor (529 +/- 113) and content of cAMP was higher significantly (P < 0.01) than that of the untreated group. The activity of PLA2 in the lung tissue is remarkably lower (146 +/- 25U) than that of untreated group (P < 0.01). The present study showed the first time the imbalance between alpha and beta adrenoceptors in the lung of rat with ARDS, and confirmed that anisodamine has a role of regulation of beta receptor, cAMP and PLA2 in the lung of RDS rat.
与对照组（490±61fmol/mg蛋白）相比，ARDS大鼠肺组织制备的细胞膜中β受体的Bmax值在损伤4小时（307±55fmol/mg蛋白）和6小时（240±66fmol/mg蛋白）后显著降低（P<0.01），而α1受体的Bmax值在损伤4小时（127±12fmol/mg蛋白）后与对照组（83±7fmol/mg蛋白）相比显著升高（P<0.01）。在山莨菪碱治疗组中，β受体的Bmax值（529±113）和cAMP含量显著高于未治疗组（P<0.01）。肺组织中PLA2的活性显著低于未治疗组（146±25U，P<0.01）。本研究首次显示ARDS大鼠肺组织中α和β肾上腺素能受体失衡，并证实山莨菪碱对RDS大鼠肺组织中的β受体、cAMP和PLA2具有调节作用。
