Wang S, Grayston J T
J Immunol. 1975 Dec;115(6):1711-6.
A new immunotype J is proposed for a group of Chlamydia trachomatis strains which are related to trachoma type C in the microimmunofluorescence typing test. Ten immunologically identical strains have been identified from four separate areas of the world. The strains were either isolated from the genital tract or from eye infection originating from the genital tract. They grow readily in HeLa 229 cell culture but poorly in egg culture. Whereas two-way cross-reactions were found between types C and J, tests with mouse antisera cross-absorbed with heterologous antigens showed that type J is completely separable from type C. The J strain caused typical follicular conjunctivitis in monkey eyes. Both humans and monkeys infected with J strains developed type-specific micro IF antibody patterns similar to immunized mouse antisera. C antisera showed broader and higher titer heterologous reactions than J antisera. Two immunologically identical strains, UW-61/Cx and 469/OC, related to both C and J, remain unclassified. They immunologically bridge the two types but are more closely related to type C immunologically and at the same time resemble type J epidemiologically and biologically.
针对沙眼衣原体菌株的一组菌株，在微量免疫荧光分型试验中与C型沙眼相关，提出了一种新的免疫型J。已从世界四个不同地区鉴定出10株免疫相同的菌株。这些菌株要么从生殖道分离，要么从源自生殖道的眼部感染中分离。它们在HeLa 229细胞培养中生长良好，但在卵黄囊培养中生长较差。虽然在C型和J型之间发现了双向交叉反应，但用异源抗原交叉吸收的小鼠抗血清进行的试验表明，J型与C型完全可分离。J菌株在猴眼中引起典型的滤泡性结膜炎。感染J菌株的人和猴都产生了与免疫小鼠抗血清相似的型特异性微量免疫荧光抗体模式。C抗血清比J抗血清显示出更广泛和更高滴度的异源反应。有两株免疫相同的菌株UW-61/Cx和469/OC，与C型和J型都相关，仍未分类。它们在免疫上连接了这两种类型，但在免疫上与C型关系更密切，同时在流行病学和生物学上类似于J型。
