Oren J
Pediatrics. 1975 Nov;56(5 pt-2 suppl):935-6.
Exercise-induced bronchospasm (EIB), as opposed to asthma precipitated by exercise, is a valuable laboratory tool in the study of the newer pharmacologic agents being developed for asthma therapy. EIB is uniquely suited for the screening of agents with cromolyn-sodium-like activity prior to extended clinical drug studies in large patient populations. To be used meaningfully, the challenge technique must be subjected to rigorous controls, standardization, and evaluation is preselected patient populations. Because of the inherent variability of the method, careful study design and the use of double-blind statistical controls are necessary to minimize misleading placebo effects.
运动诱发的支气管痉挛（EIB），与运动诱发的哮喘不同，是研究正在开发的用于哮喘治疗的新型药物的一种有价值的实验室工具。EIB特别适合在对大量患者进行长期临床药物研究之前，筛选具有色甘酸钠样活性的药物。为了有效使用，激发技术必须受到严格的控制、标准化，并且要在预先选定的患者群体中进行评估。由于该方法存在固有的变异性，因此需要精心设计研究并使用双盲统计对照，以尽量减少误导性的安慰剂效应。
