卡氏肺孢子虫肺炎并发于类风湿关节炎的低剂量甲氨蝶呤治疗。
Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis.
作者信息
Wollner A, Mohle-Boetani J, Lambert R E, Perruquet J L, Raffin T A, McGuire J L
机构信息
Respiratory Medicine Division, Stanford University Medical Center, California 94305-5236.
出版信息
Thorax. 1991 Mar;46(3):205-7. doi: 10.1136/thx.46.3.205.
Abstract
Low dose methotrexate has been used effectively for various rheumatic and non-rheumatic diseases. Three cases of Pneumocystis carinii pneumonia occurring during treatment of rheumatoid arthritis with low dose methotrexate are presented. Several mechanisms might contribute to impaired immunity and the rare development of opportunist lung infection with methotrexate. A high degree of suspicion may result in earlier diagnosis and treatment.
摘要
低剂量甲氨蝶呤已被有效用于治疗各种风湿性和非风湿性疾病。本文报告了3例在使用低剂量甲氨蝶呤治疗类风湿关节炎期间发生卡氏肺孢子虫肺炎的病例。甲氨蝶呤导致免疫功能受损和机会性肺部感染罕见发生可能有多种机制。高度怀疑可促成早期诊断和治疗。
相似文献
1
Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis.卡氏肺孢子虫肺炎并发于类风湿关节炎的低剂量甲氨蝶呤治疗。
Thorax. 1991 Mar;46(3):205-7. doi: 10.1136/thx.46.3.205.
2
3
Pneumocystis carinii pneumonia associated with methotrexate therapy in rheumatoid arthritis.类风湿关节炎患者接受甲氨蝶呤治疗后并发卡氏肺孢子虫肺炎
J Rheumatol. 1991 Aug;18(8):1254-6.
4
Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis.卡氏肺孢子虫肺炎并发于类风湿关节炎的低剂量甲氨蝶呤治疗。
Thorax. 1992 Jan;47(1):67. doi: 10.1136/thx.47.1.67.
5
Pneumocystis carinii pneumonia associated with low dose methotrexate treatment for rheumatoid arthritis.与低剂量甲氨蝶呤治疗类风湿关节炎相关的卡氏肺孢子虫肺炎
Scand J Rheumatol. 1994;23(1):51-3. doi: 10.3109/03009749409102137.
6
7
Pneumocystis jiroveci pneumonia associated with low-dose methotrexate treatment for rheumatoid arthritis: report of two cases and review of the literature.与低剂量甲氨蝶呤治疗类风湿关节炎相关的耶氏肺孢子菌肺炎：两例报告及文献复习
Mod Rheumatol. 2006;16(1):36-8. doi: 10.1007/s10165-005-0443-5.
8
[Lung diseases and treatment with methotrexate in rheumatoid arthritis].[肺部疾病与类风湿关节炎的甲氨蝶呤治疗]
Rev Pneumol Clin. 1991;47(4):179-82.
9
Pneumocystis carinii pneumonia in rheumatoid arthritis patients treated with methotrexate. A report of two cases.甲氨蝶呤治疗类风湿关节炎患者并发卡氏肺孢子虫肺炎。两例报告。
Rev Rhum Engl Ed. 1996 Jun;63(6):453-6.
10
A case of new-onset rheumatoid vasculitis becoming evident in the course of treatment for Pneumocystis jirovecii pneumonia.1例在耶氏肺孢子菌肺炎治疗过程中出现的新发类风湿性血管炎病例。
Nihon Rinsho Meneki Gakkai Kaishi. 2017;40(1):78-82. doi: 10.2177/jsci.40.78.
引用本文的文献
1
Diagnostic Challenges of Pneumocystis jirovecii Pneumonia in Methotrexate-Induced Pancytopenia: A Report on a Fatal Case and Review of the Literature.甲氨蝶呤所致全血细胞减少症合并耶氏肺孢子菌肺炎的诊断挑战：1例死亡病例报告及文献复习
Cureus. 2025 Apr 18;17(4):e82542. doi: 10.7759/cureus.82542. eCollection 2025 Apr.
2
Factors Associated with Pneumocystis jirovecii Pneumonia in Patients with Rheumatoid Arthritis Receiving Methotrexate: A Single-center Retrospective Study.类风湿关节炎患者接受甲氨蝶呤治疗后发生肺孢子菌肺炎的相关因素：一项单中心回顾性研究。
Intern Med. 2022 Apr 1;61(7):997-1006. doi: 10.2169/internalmedicine.8205-21. Epub 2021 Sep 11.
3
Pneumocystis Jiroveci Pneumonia and Newly Diagnosed Human Immunodeficiency Virus (AIDS) in a 63-Year-Old Woman.一名63岁女性的耶氏肺孢子菌肺炎与新诊断的人类免疫缺陷病毒（艾滋病）
Am J Case Rep. 2018 Aug 8;19:927-931. doi: 10.12659/AJCR.909612.
4
Histopathological Features of Methotrexate Induced Pulmonary Lesions in Rheumatoid Arthritis Patients: A Systematic Review of Case Reports.类风湿关节炎患者中氨甲蝶呤所致肺部病变的组织病理学特征：病例报告的系统评价
Open Access Maced J Med Sci. 2017 Apr 8;5(2):266-270. doi: 10.3889/oamjms.2017.049. eCollection 2017 Apr 15.
5
Pneumocystis jirovecii pneumonia in patients receiving tumor-necrosis-factor-inhibitor therapy: implications for chemoprophylaxis.接受肿瘤坏死因子抑制剂治疗患者的耶氏肺孢子菌肺炎：化学预防的意义
Curr Rheumatol Rep. 2014 Oct;16(10):445. doi: 10.1007/s11926-014-0445-4.
6
Increasing Pneumocystis pneumonia, England, UK, 2000-2010.英国英格兰地区 2000-2010 年肺囊虫肺炎发病率上升。
Emerg Infect Dis. 2013 Mar;19(3):386-92. doi: 10.3201/eid1903.121151.
7
Comparative study of intramuscular gold and methotrexate in a rheumatoid arthritis population from a socially deprived area.社会贫困地区类风湿关节炎患者群体中肌肉注射金制剂与甲氨蝶呤的对比研究。
Ann Rheum Dis. 2001 Jun;60(6):566-72. doi: 10.1136/ard.60.6.566.
8
Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.类风湿关节炎和银屑病关节炎患者中氨甲蝶呤诱发的肺炎：5例报告及文献复习
Clin Rheumatol. 1997 May;16(3):296-304. doi: 10.1007/BF02238967.
9
A risk-benefit assessment of methotrexate in corticosteroid-dependent asthma.甲氨蝶呤用于皮质类固醇依赖型哮喘的风险效益评估。
Drug Saf. 1996 Oct;15(4):283-90. doi: 10.2165/00002018-199615040-00006.
10
Methotrexate-related pulmonary complications in rheumatoid arthritis.类风湿关节炎中与甲氨蝶呤相关的肺部并发症
Ann Rheum Dis. 1994 Jul;53(7):434-9. doi: 10.1136/ard.53.7.434.
本文引用的文献
1
Pneumocystis carinii pneumonia following methotrexate therapy for rheumatoid arthritis.
Arthritis Rheum. 1983 Oct;26(10):1291-2. doi: 10.1002/art.1780261021.
2
Low dose oral methotrexate in rheumatoid arthritis: an uncontrolled trial and review of the literature.低剂量口服甲氨蝶呤治疗类风湿关节炎：一项非对照试验及文献综述
Semin Arthritis Rheum. 1983 May;12(4):333-47. doi: 10.1016/0049-0172(83)90014-8.
3
A study of the distribution of methotrexate in human tissues and tumors.甲氨蝶呤在人体组织和肿瘤中的分布研究。
Cancer Res. 1970 May;30(5):1344-8.
4
Pulmonary disease in the immunocompromised host (2).免疫功能低下宿主的肺部疾病（2）
Mayo Clin Proc. 1985 Sep;60(9):610-31. doi: 10.1016/s0025-6196(12)60985-9.
5
Fatal infections in systemic lupus erythematosus: the role of opportunistic organisms.系统性红斑狼疮中的致命感染：机会性生物体的作用
Medicine (Baltimore). 1987 Sep;66(5):341-8. doi: 10.1097/00005792-198709000-00002.
6
Methotrexate in rheumatoid arthritis. Health and Public Policy Committee, American College of Physicians.
Ann Intern Med. 1987 Sep;107(3):418-9.
7
Immunologic studies of rheumatoid arthritis patients treated with methotrexate.
Arthritis Rheum. 1987 May;30(5):481-8. doi: 10.1002/art.1780300501.
8
Methotrexate in the treatment of corticosteroid-dependent asthma. A double-blind crossover study.甲氨蝶呤治疗糖皮质激素依赖型哮喘。一项双盲交叉研究。
N Engl J Med. 1988 Mar 10;318(10):603-7. doi: 10.1056/NEJM198803103181004.
9
Folate status of rheumatoid arthritis patients receiving long-term, low-dose methotrexate therapy.接受长期低剂量甲氨蝶呤治疗的类风湿关节炎患者的叶酸状态
Arthritis Rheum. 1987 Dec;30(12):1348-56. doi: 10.1002/art.1780301205.
10
Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for psoriatic arthropathy.卡氏肺孢子虫肺炎并发低剂量甲氨蝶呤治疗银屑病关节炎。
Ann Rheum Dis. 1989 Mar;48(3):247-9. doi: 10.1136/ard.48.3.247.
Zotero 插件