Longley R E, Gunasekera S P, Faherty D, Mclane J, Dumont F
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Fort Pierce, Florida 34946.
Ann N Y Acad Sci. 1993 Nov 30;696:94-107. doi: 10.1111/j.1749-6632.1993.tb17145.x.
In summary, discodermolide, a novel, marine-derived compound, is a potent in vitro and in vivo immunosuppressive agent. Discodermolide blocks cellular proliferation in lymphoid and nonlymphoid cells. This blocking action is not due to cytotoxicity. Blockage of cell proliferation by discodermolide appears to occur at the G2/M interface of the cell cycle, similar to that observed with other types of antiproliferative drugs (i.e., doxorubicin). The cell cycle block appears to be reversible, as cells recover normal cycling patterns within 48 h after removal of the compound. Additional work with this compound is targeted towards determining the exact nature of discodermolide's mitotic block and is currently under way.
总之，Discodermolide是一种新型的、源自海洋的化合物，是一种强效的体外和体内免疫抑制剂。Discodermolide可阻断淋巴细胞和非淋巴细胞的细胞增殖。这种阻断作用并非由于细胞毒性。Discodermolide对细胞增殖的阻断似乎发生在细胞周期的G2/M期，这与其他类型的抗增殖药物（如阿霉素）所观察到的情况相似。细胞周期阻滞似乎是可逆的，因为在去除该化合物后48小时内细胞恢复正常的循环模式。针对该化合物的进一步研究旨在确定Discodermolide有丝分裂阻滞的确切性质，目前正在进行中。
