新生霉素对粪肠球菌多重耐药菌株的体外活性
In vitro activity of novobiocin against multiresistant strains of Enterococcus faecium.
作者信息
French P, Venuti E, Fraimow H S
机构信息
Dorrance H. Hamilton Laboratories, Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania 19107.
出版信息
Antimicrob Agents Chemother. 1993 Dec;37(12):2736-9. doi: 10.1128/AAC.37.12.2736.
Abstract
Sixty strains of vancomycin- and ampicillin-resistant Enterococcus faecium were evaluated for their susceptibilities to novobiocin in vitro. In Mueller-Hinton broth, novobiocin inhibited all strains when it was used at a concentration of < or = 2 microgram/ml and 40 of 60 strains when it was used at a concentration of < or = 0.5 micrograms/ml. MICs were 8- to 16-fold higher in 50% serum. Novobiocin alone resulted in 2-log-unit killing at 24 h. Combinations of novobiocin and a fluoroquinolone (either ciprofloxacin or ofloxacin) were additive and bactericidal for quinolone-susceptible strains in either broth or 50% serum. Gentamicin did not affect novobiocin activity, and rifampin and doxycycline were antagonistic.
摘要
对60株耐万古霉素和氨苄西林的粪肠球菌进行了体外新霉素敏感性评估。在穆勒-欣顿肉汤中，当新霉素浓度≤2微克/毫升时可抑制所有菌株，当浓度≤0.5微克/毫升时可抑制60株中的40株。在50%血清中，最低抑菌浓度（MIC）高8至16倍。单独使用新霉素在24小时时可导致2个对数单位的杀菌效果。新霉素与氟喹诺酮类药物（环丙沙星或氧氟沙星）联合使用对肉汤或50%血清中的喹诺酮敏感菌株具有相加和杀菌作用。庆大霉素不影响新霉素活性，利福平和强力霉素具有拮抗作用。
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