Klinger W, Müller D, Ankermann H
Acta Biol Med Ger. 1975;34(4):661-6.
Ephedrine and propranolol shorten hexobarbital sleeping time and increase amidopyrine-N-demethylation activity. Pholedrine only scarcely acts on these parameters, dihydroergotamine is effective. In vitro, ephedrine, pholedrine, propranolol and above all dihydroergotamine proved to be inhibitors of amidopyrine-N-demethylation. Noradrenaline, cAMP and dibutyryli cAMP were ineffective. An influence of the sympathetic nervous system on biotransformation activity cannot be recognized.
麻黄碱和普萘洛尔可缩短己巴比妥睡眠时间并提高氨基比林 - N - 脱甲基化活性。去氧麻黄碱对这些参数几乎没有作用，双氢麦角胺则有效。在体外，麻黄碱、去氧麻黄碱、普萘洛尔尤其是双氢麦角胺被证明是氨基比林 - N - 脱甲基化的抑制剂。去甲肾上腺素、环磷酸腺苷（cAMP）和二丁酰环磷腺苷（dibutyryli cAMP）无效。无法识别交感神经系统对生物转化活性的影响。
