某些曲霉属物种产杂色曲霉素及其对鸡胚的毒性。
Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos.
作者信息
Schroeder H W, Kelton W H
出版信息
Appl Microbiol. 1975 Oct;30(4):589-91. doi: 10.1128/am.30.4.589-591.1975.
Abstract
Sterigmatocystin was produced by 59% of Aspergillus flavus cultures and by 16% of A. parasiticus cultures. All sterigmatocystin-producing cultures of the A. flavus group also simultaneously produced aflatoxin or O-methylsterigmatocystin. Sterigmatocystin was produced by A. chevalieri, A. ruber, and A. amstelodami, species not previously reported to produce the compound. In 5-day-old chicken embryos, the no-effect level of toxicity of sterigmatocystin was between 1 and 2 mug/egg; the mean lethal dose was 5 to 7 mug; and 90 to 100% of the embryos were killed with 10 mug. Teratogenic effects and weight reduction were generally associated with nonlethal doses.
摘要
59%的黄曲霉培养物和16%的寄生曲霉培养物可产生柄曲霉素。黄曲霉组所有产生柄曲霉素的培养物同时也会产生黄曲霉毒素或O - 甲基柄曲霉素。谢瓦利埃曲霉、红曲霉和阿姆斯特丹曲霉也可产生柄曲霉素，此前未有报道称这些菌种能产生该化合物。在5日龄鸡胚中，柄曲霉素的无作用毒性水平为每枚鸡蛋1至2微克；平均致死剂量为5至7微克；10微克可杀死90%至100%的胚胎。致畸作用和体重减轻通常与非致死剂量有关。
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