Li P, de Groot K
Department of Biomaterials, Leiden University School of Medicine, The Netherlands.
J Biomed Mater Res. 1993 Dec;27(12):1495-500. doi: 10.1002/jbm.820271205.
Calcium phosphate formation is induced within sol-gel prepared titania and grows toward a calcium phosphate solution in which the titania is immersed. The implantation of this sol-gel prepared titania film coating on TiA16V4 core into the femurs of goats shows an accumulation of calcium phosphate within the titania film 12 weeks postoperatively, which leads to the connection of the titania film coating to the bone. Therefore, sol-gel prepared titania is probably bioactive. The results indicate that hydrated titania gel is able to generate calcium phosphate by intake of calcium and phosphate from the surrounding solution. Sufficient TiOH concentration at the titania surface is needed to start this process. Titanium could be bioactive, if its hydrolysis can be accelerated.
在溶胶 - 凝胶法制备的二氧化钛中诱导形成磷酸钙，并朝着浸入二氧化钛的磷酸钙溶液生长。将这种在TiA16V4核心上通过溶胶 - 凝胶法制备的二氧化钛薄膜涂层植入山羊股骨后，术后12周在二氧化钛薄膜内显示出磷酸钙的积累，这导致二氧化钛薄膜涂层与骨相连。因此，溶胶 - 凝胶法制备的二氧化钛可能具有生物活性。结果表明，水合二氧化钛凝胶能够通过从周围溶液中摄取钙和磷来生成磷酸钙。开始这个过程需要在二氧化钛表面有足够的TiOH浓度。如果钛的水解能够加速，那么钛可能具有生物活性。
