Peltola T, Pätsi M, Rahiala H, Kangasniemi I, Yli-Urpo A
Institute of Dentistry, University of Turku, Finland.
J Biomed Mater Res. 1998 Sep 5;41(3):504-10. doi: 10.1002/(sici)1097-4636(19980905)41:3<504::aid-jbm22>3.0.co;2-g.
Titanium and its alloys are used widely in the manufacture of orthopedic and dental implants. Sol-gel-prepared titania is able to stimulate bone-like apatite formation in in vitro and in vivo cultures. These materials can be used, for example, as coatings on dental and orthopedic implants. However, the processes that lead to apatite formation are not fully understood. In this study different kinds of titania coatings on commercially pure titanium (c.p. Ti) were tested for apatite-forming ability. The rate of apatite formation is considered to be descriptive of a material's bioactive (bone-bonding) potential. Apatite-forming tests were done in simulated body fluid (SBF). Apatite-forming ability was highest with the addition of valeric acid to sol (600 degrees C) or with sintering sol-gel coatings at 450 degrees-550 degrees C. At that temperature range calcium phosphate forms on the coatings in 1 week. Calcium phosphate forming is observed in 1 day on standard coatings sintered at 500 degrees C.
钛及其合金在骨科和牙科植入物制造中被广泛应用。溶胶 - 凝胶法制备的二氧化钛能够在体外和体内培养中刺激类骨磷灰石的形成。这些材料可用于，例如，作为牙科和骨科植入物的涂层。然而，导致磷灰石形成的过程尚未完全了解。在本研究中，对商业纯钛（c.p. Ti）上不同种类的二氧化钛涂层进行了磷灰石形成能力测试。磷灰石形成速率被认为是材料生物活性（骨结合）潜力的描述指标。磷灰石形成测试在模拟体液（SBF）中进行。向溶胶（600℃）中添加戊酸或在450℃ - 550℃烧结溶胶 - 凝胶涂层时，磷灰石形成能力最高。在该温度范围内，涂层上在1周内形成磷酸钙。在500℃烧结的标准涂层上，1天内即可观察到磷酸钙的形成。
