Audibert F, Chedid L
C R Acad Hebd Seances Acad Sci D. 1975 Apr 7;280(13):1629-32.
Though highly efficient, Freund's adjuvant has serious limitations because it contains mineral oil and isomannide monooleate emulsifier (arlacel A). The present study describes the conditions under which a stable water in oil emulsion can be produced by using metabolizable peanut oil with arlacel. When mycobacteria are added, a potent emulsified oil adjuvant is obtained which increases the immune response to BSA and to influenza vaccine.
尽管弗氏佐剂效率很高，但它有严重的局限性，因为它含有矿物油和异山梨醇单油酸酯乳化剂（司盘80）。本研究描述了使用可代谢的花生油和司盘80生产稳定的油包水乳液的条件。当加入分枝杆菌时，可得到一种有效的乳化油佐剂，它能增强对牛血清白蛋白和流感疫苗的免疫反应。
