Parant M, Audibert F, Parant F, Chedid L, Soler E, Polonsky J, Lederer E
Infect Immun. 1978 Apr;20(1):12-9. doi: 10.1128/iai.20.1.12-19.1978.
Mycobacterial cord factors (6,6'-diesters of trehalose with mycolic acids ranging from C80 to C90) have been shown to protect mice effectively against infection with Klebsiella pneumoniae or with Listeria monocytogenes. Our present findings indicate that the low-molecular-weight cord factor of Corynebacterium diphtheriae (with corynomycolic acids ranging from C28 PTO C36) is equally active. Moreover, its synthetic analog (with synthetic C32 mycolic acid) has the same activity. Two lower synthetic 6,6'-diesters of trehalose with C22 acids, which are described here for the first time, as well as dipalmitate and a dioleate of sucrose, were found inactive. The synthetic C76 trehalose diesters, which are capable of enhancing nonspecific resistance to infection, increase the immune response in mice, even when injected in metabolizable oil. They induce in the injected paws an inflammatory process weaker and more transient than the natural cord factor.
分枝杆菌索状因子（海藻糖与碳链长度为C80至C90的分枝菌酸形成的6,6'-二酯）已被证明能有效保护小鼠免受肺炎克雷伯菌或单核细胞增生李斯特菌感染。我们目前的研究结果表明，白喉棒状杆菌的低分子量索状因子（碳链长度为C28至C36的棒状分枝菌酸）同样具有活性。此外，其合成类似物（含合成C32分枝菌酸）也具有相同活性。首次在此描述的两种较低分子量的海藻糖与C22酸形成的6,6'-二酯，以及蔗糖二棕榈酸酯和二油酸酯，均无活性。能够增强对感染的非特异性抵抗力的合成C76海藻糖二酯，即使注射到可代谢油中，也能增强小鼠的免疫反应。它们在注射的爪子中引发的炎症过程比天然索状因子更弱且更短暂。
