微小棒状杆菌增强对实验性克氏锥虫感染的抵抗力并抑制免疫反应。
Enhancement of resistance and suppression of immunization against experimental Trypanosoma cruzi infection by Corynebacterium parvum.
作者信息
Kierszenbaum F
出版信息
Infect Immun. 1975 Nov;12(5):1227-9. doi: 10.1128/iai.12.5.1227-1229.1975.
Abstract
Intravenous but not intraperitoneal injection of killed Corynebacterium parvum either before or after intraperitoneal infection with the highly reticulotropic Tulahuén strain of Trypanosoma cruzi produced enhanced resistance against the infection in mice. In contrast, C. parvum had no effect when the infection was caused with the predominately myotropic Y strain of T. cruzi. C. parvum given intravenously before immunization with killed culture forms of the Y strain parasite consistently diminished the protective effect against subsequent infection, which could be obtained with antigen alone.
摘要
在腹腔感染高网状嗜性克氏锥虫图拉韦恩株之前或之后，静脉注射而非腹腔注射灭活的微小棒状杆菌可增强小鼠对该感染的抵抗力。相比之下，当由主要嗜肌性的克氏锥虫Y株引起感染时，微小棒状杆菌没有效果。在用Y株寄生虫的灭活培养形式进行免疫之前静脉注射微小棒状杆菌，始终会降低对后续感染的保护作用，而单独使用抗原则可获得这种保护作用。
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