新生儿的静态呼吸顺应性。II：其在改善早期表面活性剂治疗婴儿选择方面的潜力。
Static respiratory compliance in the newborn. II: Its potential for improving the selection of infants for early surfactant treatment.
作者信息
Wilkie R A, Bryan M H, Tarnow-Mordi W O
机构信息
Department of Child Health, University of Dundee, Ninewells Hospital and Medical School.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1994 Jan;70(1):F16-8. doi: 10.1136/fn.70.1.f16.
Static respiratory system compliance (Crs) and lecithin/sphingomyelin (L/S) ratios in tracheal aspirates were estimated in two independent groups of mechanically ventilated infants. Crs was measured rapidly at the cotside using a passive expiratory flow technique and L/S ratios were estimated in the laboratory by high performance liquid chromatography. In the reference group of 22 infants, Crs < 1.8 ml/cm H2O/m predicted surfactant deficiency with a positive predictive value of 100% and a negative predictive value of 92%. In the validation group of 23 infants, Crs < 1.8 ml/cm H2O/m predicted surfactant deficiency with a positive predictive value of 94% and a negative predictive value of 83%. Measurement of static Crs is a rapid, non-invasive technique which may usefully supplement current methods of selecting infants at high risk of respiratory distress syndrome.
在两组独立的机械通气婴儿中，评估了气管吸出物中的静态呼吸系统顺应性（Crs）和卵磷脂/鞘磷脂（L/S）比值。使用被动呼气流量技术在床边快速测量Crs，并在实验室通过高效液相色谱法估计L/S比值。在22名婴儿的参考组中，Crs<1.8 ml/cm H2O/m预测表面活性剂缺乏，阳性预测值为100%，阴性预测值为92%。在23名婴儿的验证组中，Crs<1.8 ml/cm H2O/m预测表面活性剂缺乏，阳性预测值为94%，阴性预测值为83%。静态Crs测量是一种快速、非侵入性技术，可有效补充当前选择呼吸窘迫综合征高危婴儿的方法。
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