美国普通人群及特定亚人群脂肪组织中的二噁英和二苯并呋喃。
Dioxins and dibenzofurans in adipose tissue of the general US population and selected subpopulations.
作者信息
Orban J E, Stanley J S, Schwemberger J G, Remmers J C
机构信息
Battelle Memorial Institute, Columbus, Ohio.
出版信息
Am J Public Health. 1994 Mar;84(3):439-45. doi: 10.2105/ajph.84.3.439.
OBJECTIVES
The Environmental Protection Agency's National Human Adipose Tissue Survey (NHATS) was conducted in fiscal year (FY) 1987 to (1) estimate average concentrations of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in the adipose tissue of humans in the US population, (2) identify differences in average concentrations among subpopulations, and (3) compare average concentrations with those from the FY 1982 NHATS:
METHODS
Population estimates of the average levels of PCDDs and PCDFs were established on the basis of 865 human adipose tissue specimens collected in FY 1987. Average levels among subpopulations were compared.
RESULTS
The average concentration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the adipose tissue of the US population was 5.38 pg/g, increasing from 1.98 pg/g in children under 14 years of age to 9.40 pg/g in adults over 45. The effect of age was significant for nine compounds. Regional differences in the levels of 2,3,4,7,8-pentachlorinated dibenzofurans were statistically significant, but there were no significant differences associated with sex or race.
CONCLUSIONS
The survey provides a baseline of average levels of PCDDs and PCDFs in the adipose tissue of humans in the US population.
目的
美国环境保护局在1987财年开展了国家人体脂肪组织调查（NHATS），以（1）估计美国人群人体脂肪组织中多氯二苯并对二噁英（PCDDs）和多氯二苯并呋喃（PCDFs）的平均浓度，（2）确定亚人群之间平均浓度的差异，以及（3）将平均浓度与1982财年NHATS的浓度进行比较。
方法
基于1987财年收集的865份人体脂肪组织标本，确定了PCDDs和PCDFs平均水平的人群估计值。比较了亚人群之间的平均水平。
结果
美国人群脂肪组织中2,3,7,8-四氯二苯并对二噁英的平均浓度为5.38皮克/克，从14岁以下儿童的1.98皮克/克增加到45岁以上成年人的9.40皮克/克。年龄对9种化合物有显著影响。2,3,4,7,8-五氯二苯并呋喃水平的区域差异具有统计学意义，但与性别或种族无关的差异不显著。
结论
该调查提供了美国人群人体脂肪组织中PCDDs和PCDFs平均水平的基线。
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