Inhibitory effect of deferoxamine or macrophage activation on transformation of Paracoccidioides brasiliensis conidia ingested by macrophages: reversal by holotransferrin.
作者信息
Cano L E, Gomez B, Brummer E, Restrepo A, Stevens D A
机构信息
Corporacion para Investigaciones Biologicas, Hospital Pablo Tobon Uribe, Medellin, Colombia.
出版信息
Infect Immun. 1994 Apr;62(4):1494-6. doi: 10.1128/iai.62.4.1494-1496.1994.
Abstract
Conidia of P. brasiliensis ingested by murine macrophages at 37 degrees C showed enhanced transformation to yeast cells and further intracellular growth compared with conidia in culture medium alone. Treatment of macrophages with the iron chelator deferoxamine inhibited the intracellular conidium-to-yeast transformation. Cytokine-activated macrophages could also exert this inhibitory effect. Holotransferrin reversed the inhibitory effect of either deferoxamine or activated macrophages on intracellular conidium-to-yeast transformation. These results indicate that iron restriction is one of the mechanisms by which activated macrophages control the intracellular transformation of ingested conidia and growth of yeast cells.
摘要
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本文引用的文献
1
Paracoccidioidomycosis: an update.
Clin Microbiol Rev. 1993 Apr;6(2):89-117. doi: 10.1128/CMR.6.2.89.
2
Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma.
J Clin Invest. 1993 Mar;91(3):969-76. doi: 10.1172/JCI116318.
3
Comparison of various techniques for determining viability of Paracoccidioides brasiliensis yeast-form cells.
J Clin Microbiol. 1982 Jul;16(1):209-11. doi: 10.1128/jcm.16.1.209-211.1982.
4
Expression of the transferrin receptor in murine peritoneal macrophages is modulated in the different stages of activation.
J Immunol. 1984 May;132(5):2285-90.
5
Expression of the transferrin receptor on murine peritoneal macrophages is modulated by in vitro treatment with interferon gamma.
Cell Immunol. 1984 Dec;89(2):478-88. doi: 10.1016/0008-8749(84)90348-4.
6
The site of action of desferrioxamine.
Br J Haematol. 1971 Apr;20(4):395-404. doi: 10.1111/j.1365-2141.1971.tb07051.x.
7
Morphological development of the conidia produced by Paracoccidioides brasiliensis mycelial form.
J Med Vet Mycol. 1986 Aug;24(4):337-9.
8
A technique to collect and dislodge conidia produced by Paracoccidioides brasiliensis mycelial form.
J Med Vet Mycol. 1986 Jun;24(3):247-50.
9
Experimental murine paracoccidiodomycosis induced by the inhalation of conidia.
J Med Vet Mycol. 1987 Jun;25(3):165-75. doi: 10.1080/02681218780000231.
10
Gamma-interferon activation of macrophages for killing of Paracoccidioides brasiliensis and evidence for nonoxidative mechanisms.
Int J Immunopharmacol. 1988;10(8):945-52. doi: 10.1016/0192-0561(88)90041-0.
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