从海绵近似简单扁海绵（Plakortis aff. simplex）中分离出的四种新型C16 1,2 - 二氧杂环己烯 - 聚酮化合物。

Four new C16 1,2-dioxene-polyketides from the sponge Plakortis aff. simplex.

作者信息

Rudi A, Talpir R, Kashman Y, Benayahu Y, Schleyer M

机构信息

Department of Zoology, Tel Aviv University, Israel.

出版信息

J Nat Prod. 1993 Dec;56(12):2178-82. doi: 10.1021/np50102a023.

DOI:10.1021/np50102a023

PMID:8133301

Abstract

Two new cyclic peroxide-containing polyketide C16 acids 2 and 4 with their methyl esters 3 and 5 have been isolated from the Indo-Pacific marine sponge Plakortis aff. simplex. Both 2 and 3 are proposed to contain a single 1,2-dioxene ring, while 4 and 5 incorporate two 1,2-dioxene rings. The structures were elucidated mainly through 1D and 2D nmr spectral analysis. The methyl esters 3 and 5 were found to be active against cultured P-388 murine leukemia cells.

摘要

从印度-太平洋海域的海绵Plakortis aff. simplex中分离出了两种新的含环状过氧化物的聚酮C16酸2和4及其甲酯3和5。化合物2和3被认为含有一个1,2-二氧杂环己烯环，而4和5则含有两个1,2-二氧杂环己烯环。其结构主要通过一维和二维核磁共振光谱分析得以阐明。发现甲酯3和5对培养的P-388小鼠白血病细胞具有活性。