Maillard J C, Palin C, Trap I, Bensaid A
CIRAD-EMVT, Pointe-à-Pitre, Guadeloupe.
Rev Elev Med Vet Pays Trop. 1993;46(1-2):291-5.
Dermatophilosis is a disease associated with the tick Amblyomma variegatum, and a genetic predisposition to the manifestation of symptoms has been demonstrated. Indeed, the Creole cattle of Guadeloupe constitute a population which is highly resistant to this disease, whereas the Brahman zebu cattle of Martinique seem very susceptible. However, in this Brahman population there is a gradient regarding the severity of symptoms depending on individuals. In several herds of these pure zebu Brahman, kept under the same farming conditions, we selected susceptible and resistant groups because of the simultaneous presence of animals affected or not by clinical dermatophilosis. In these animals we studied several highly polymorphic genetic systems such as haemoglobin, albumin, the BoLA Complex (class I and II) and the gamma S crystallin gene. Only exon 2 of the BoLA-DRB3 gene, investigated by PCR-RFLP technique, showed interesting polymorphisms. We have established a genotypic map showing at least 4 different alleles of which 1 seems particular to one animal susceptible to dermatophilosis. Before reaching any conclusion further investigations with more DNA samples of susceptible animals are needed.
皮肤嗜皮菌病是一种与变异革蜱相关的疾病，并且已经证明存在症状表现的遗传易感性。事实上，瓜德罗普岛的克里奥尔牛群体对这种疾病具有高度抗性，而马提尼克岛的婆罗门瘤牛似乎非常易感。然而，在这个婆罗门群体中，症状的严重程度因个体而异。在这些纯瘤牛婆罗门的几个牛群中，在相同的养殖条件下，由于同时存在受临床皮肤嗜皮菌病影响或未受影响的动物，我们选择了易感和抗性群体。在这些动物中，我们研究了几个高度多态的遗传系统，如血红蛋白、白蛋白、牛白细胞抗原复合体（I类和II类）以及γS晶状体蛋白基因。通过聚合酶链反应 - 限制性片段长度多态性技术研究的牛白细胞抗原 - DRB3基因的外显子2仅显示出有趣的多态性。我们已经建立了一个基因型图谱，显示至少4种不同的等位基因，其中1种似乎是一只易患皮肤嗜皮菌病的动物所特有的。在得出任何结论之前，需要用更多易感动物的DNA样本进行进一步研究。
