Matsumoto A H, Reifsnyder A C, Hartwell G D, Angle J F, Selby J B, Tegtmeyer C J
Department of Radiology, University of Virginia Health Sciences Center, Charlottesville 22908.
J Vasc Interv Radiol. 1994 Jan-Feb;5(1):171-5. doi: 10.1016/s1051-0443(94)71478-0.
A prospective, double-blind study was undertaken to evaluate the effect of using a buffered lidocaine solution on the perception of pain experienced by a patient during its intradermal injection.
One hundred fifty patients undergoing diagnostic angiographic and interventional procedures at the authors' institution were randomly assigned to receive a 1-mL aliquot of one of three lidocaine solutions: plain 1% lidocaine, 1% lidocaine diluted with normal saline in a 10:1 ratio, and 1% lidocaine diluted with 8.4% sodium bicarbonate in a 10:1 ratio. The lidocaine solutions were administered intradermally over 10-15 seconds. A numerical value was placed on the patient's perception of pain, separate from that associated with the 25-gauge needle insertion, with use of a linear visual analog scale.
Mean pain scores were as follows: for the 1% lidocaine solution, 2.83 +/- 2.60; for 1% lidocaine plus normal saline solution, 2.89 +/- 2.34; and for 1% lidocaine plus sodium bicarbonate solution, 1.37 +/- 1.73 (P = .0018).
Buffering lidocaine significantly decreased the discomfort associated with its administration as a local anesthetic.
进行一项前瞻性双盲研究，以评估使用缓冲利多卡因溶液对患者皮内注射时疼痛感知的影响。
在作者所在机构接受诊断性血管造影和介入手术的150例患者被随机分配接受三种利多卡因溶液之一的1毫升等分试样：普通1%利多卡因、以10:1比例用生理盐水稀释的1%利多卡因、以及以10:1比例用8.4%碳酸氢钠稀释的1%利多卡因。利多卡因溶液在10 - 15秒内进行皮内注射。使用线性视觉模拟量表，对患者与25号针头插入无关的疼痛感知进行数值评分。
平均疼痛评分如下：1%利多卡因溶液为2.83±2.60；1%利多卡因加生理盐水溶液为2.89±2.34；1%利多卡因加碳酸氢钠溶液为1.37±1.73（P = 0.0018）。
缓冲利多卡因可显著降低其作为局部麻醉剂给药时的不适感。
