Epstein J B, Marcoe J H
British Columbia Cancer Agency, Vancouver General Hospital, University of British Columbia, Canada.
Oral Surg Oral Med Oral Pathol. 1994 Feb;77(2):135-40. doi: 10.1016/0030-4220(94)90275-5.
Neuropathic pain may be a major cause of pain in the head and neck. Trigeminal neuralgia may appear as intraoral pain. This article reviews a series of 24 consecutive cases of oral pain treated with topical capsaicin. Complete remission of neuropathic pain was seen in 31.6% of patients; partial remission was achieved in 31.6% of patients. Trigeminal neuralgia with an intraoral trigger was less responsive to topical therapy than neuropathic pain. Further study is needed to clarify the efficacy of topical capsaicin in neuropathic and neuralgic pain and the effect of differing dosages and frequency of application. On the basis of the findings in this open-label clinical trial, controlled clinical study of capsaicin in neuropathic oral pain states appears warranted.
神经性疼痛可能是头颈部疼痛的主要原因。三叉神经痛可能表现为口腔内疼痛。本文回顾了连续24例接受辣椒素局部治疗的口腔疼痛病例。31.6%的患者神经性疼痛完全缓解；31.6%的患者部分缓解。伴有口腔内触发点的三叉神经痛对局部治疗的反应不如神经性疼痛。需要进一步研究以阐明辣椒素局部治疗在神经性疼痛和神经痛中的疗效以及不同剂量和应用频率的效果。基于这项开放标签临床试验的结果，对辣椒素治疗神经性口腔疼痛状态进行对照临床研究似乎是必要的。
