Monroy-Ostria A, Monroy-Ostria T J, Gómez G J, Hernández M O
Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, México, D.F., Mexico.
Rev Latinoam Microbiol. 1993 Jan-Mar;35(1):91-8.
Golden hamsters were infected orally with viable cysticerci of Taenia solium obtained from infected pigs. After two weeks of infection implanted scolices of about 4 mm were found in exactly the same number as the number of ingested cysticerci. At six weeks 66% of the ingested cysticerci were found as implanted tapeworms (average size: 5.7 cm). At ten weeks 16% of the ingested cysticerci were found as implanted tapeworms (average size: 5.8 cm). At 14 weeks no tapeworms were found. Skin tests with taenia extracts were positive after 9 weeks of infection peaked at 12 and 14 weeks and declined afterwards becoming negative after 27 weeks. Skin test with cysticercus extracts were weaker, peaked at 8 and 10 weeks, were very low after 12 weeks and became negative after 16 weeks. Histological studies in the attachment site at the small intestine showed at 2 weeks a cellular infiltrate formed by macrophages, epithelioid cells and some plasma cells, there was very little alteration of epithelium. At 6 and 8 weeks the epithelium was damaged and necrotized. At 17 and 19 weeks the lesion started to resolve. We conclude that the golden hamster can be used to reproduce in the laboratory at least part of the life cycle of Taenia solium.
将金黄仓鼠经口感染从受感染猪身上获取的猪带绦虫活囊尾蚴。感染两周后，发现植入的头节约4毫米，数量与摄入的囊尾蚴数量完全相同。六周时，66%摄入的囊尾蚴被发现为植入的绦虫（平均长度：5.7厘米）。十周时，16%摄入的囊尾蚴被发现为植入的绦虫（平均长度：5.8厘米）。十四周时未发现绦虫。感染九周后用绦虫提取物进行皮肤试验呈阳性，在十二周和十四周达到峰值，之后下降，二十七周后变为阴性。用囊尾蚴提取物进行皮肤试验反应较弱，在八周和十周达到峰值，十二周后非常低，十六周后变为阴性。小肠附着部位的组织学研究显示，两周时由巨噬细胞、上皮样细胞和一些浆细胞形成细胞浸润，上皮几乎没有改变。六周和八周时上皮受损并坏死。十七周和十九周时病变开始消退。我们得出结论，金黄仓鼠可用于在实验室再现猪带绦虫生命周期的至少一部分。
