Cowell I G
Department of Biochemistry and Genetics, Medical School, University of Newcastle Upon Tyne, UK.
Trends Biochem Sci. 1994 Jan;19(1):38-42. doi: 10.1016/0968-0004(94)90172-4.
Studies on the regulation of transcription often focus on mechanisms of transcriptional activation. However, transcriptional repression is also an important factor in the regulation of many genes. Transcription of specific genes can be downregulated in various ways, and examination of a number of different systems has revealed that most or all steps required for transcriptional activation can be interfered with by transcriptional repressors.
对转录调控的研究通常聚焦于转录激活机制。然而，转录抑制也是许多基因调控中的一个重要因素。特定基因的转录可以通过多种方式下调，对多个不同系统的研究表明，转录激活所需的大多数或所有步骤都可能受到转录抑制因子的干扰。
