Söderholm A L, Pukkala E, Lindqvist C, Teppo L
Department of Oral and Maxillofacial Surgery, Helsinki University Hospital, Finland.
Br J Cancer. 1994 Apr;69(4):784-7. doi: 10.1038/bjc.1994.148.
The relative risk of subsequent cancers was evaluated for a total of 9,092 patients with lip and oropharyngeal cancer recorded between 1953 and 1989 in the nationwide Finnish Cancer Registry. The observed numbers of patients were compared with those expected on the basis of the incidence rates in the Finnish population. There were 1,130 patients (12%) with a new cancer. The standardised incidence ratio (SIR) of contracting a new primary cancer was 1.2 for lip cancer patients (95% CI 1.1-1.3) and 1.4 for patients with oropharyngeal cancer (95% CI 1.2-1.4). Among lip cancer patients, a statistically significant excess risk was found for subsequent cancers in the oropharyngeal area (SIR 1.9, 95% CI 1.1-3.1), larynx (SIR 2.0, 95% CI 1.2-2.9) and lung (SIR 1.4, 95% CI 1.3-1.6), i.e. for cancers with tobacco aetiology. Among patients with oropharyngeal cancer there was an excess of lip cancer (SIR, 3.5, 95% CI 1.5-6.9), lung cancer (SIR 1.8, 95% CI 1.3-2.3) and leukaemia (SIR 2.3, 95% CI 1.0-4.3). Radiotherapy for the first primary did not increase the risk of new cancer.
在芬兰全国癌症登记处记录的1953年至1989年间确诊的9092例唇癌和口咽癌患者中，评估了后续患癌的相对风险。将观察到的患者数量与基于芬兰人群发病率预期的数量进行比较。有1130例患者（12%）患了新的癌症。唇癌患者患新发原发性癌症的标准化发病率（SIR）为1.2（95%置信区间1.1 - 1.3），口咽癌患者为1.4（95%置信区间1.2 - 1.4）。在唇癌患者中，发现口咽区域（SIR 1.9，95%置信区间1.1 - 3.1）、喉（SIR 2.0，95%置信区间1.2 - 2.9）和肺（SIR 1.4，95%置信区间1.3 - 1.6）后续患癌存在统计学上显著的额外风险，即由烟草病因导致的癌症。在口咽癌患者中，唇癌（SIR 3.5，95%置信区间1.5 - 6.9）、肺癌（SIR 1.8，95%置信区间1.3 - 2.3）和白血病（SIR 2.3，95%置信区间1.0 - 4.3）的发病率有所增加。首次原发性癌症的放疗并未增加患新癌症的风险。
