Negrete R E, Backhouse N, Cajigal I, Delporte C, Cassels B K, Breitmaier E, Eckhardt G
Pharmacognosy Laboratory, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago.
J Ethnopharmacol. 1993 Dec;40(3):149-53. doi: 10.1016/0378-8741(93)90062-a.
Two previously undescribed elemanolide esters, the 2-methylpropanoate and 2-methyl-2-propenoate of 11,13-dehydromelitensin, were isolated in the course of a bioassay-guided fractionation from the aerial parts of Centaurea chilensis Hook. et Arn., used traditionally to treat 'gout and rheumatism'. The mixture of both substances exhibits anti-inflammatory activity in the carrageenan-induced paw edema assay.
从传统上用于治疗“痛风和风湿”的智利矢车菊（Centaurea chilensis Hook. et Arn.）地上部分进行生物活性导向分离过程中，分离出了两种之前未描述过的榄烷型倍半萜内酯酯，即11,13-脱氢美里亭新碱的2-甲基丙酸酯和2-甲基-2-丙烯酸酯。这两种物质的混合物在角叉菜胶诱导的爪肿胀试验中表现出抗炎活性。
