Alvarez M E, Rotelli A E, Pelzer L E, Saad J R, Giordano O
Area de Química Orgánica, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, Argentina.
Farmaco. 2000 Jun-Jul;55(6-7):502-5. doi: 10.1016/s0014-827x(00)00067-7.
The chemical study of aerial parts of Lampaya hieronymi Schum. ex Moldenke yielded oleanolic acid, epi-oleanolic acid, epi-maslinic acid, 4'7-dimethoxyapigenin, p-hydroxyacetophenone, and p-hydroxyacetophenone-beta-glucoside. In searching for natural products as potential anti-inflammatory agents, all the compounds, except 4'7-dimethoxyapigenin were evaluated in vivo for their ability to inhibit acute inflammation. Our studies demonstrated that p-hydroxyacetophenone and the triterpenes produced protective effects in carrageenan induced paw edema in mouse, at 1-3 h and 3-5 h, respectively, after the injection of carrageenan. These results indicated that their effects might correlate with the release of histamine, serotonin, kinin and prostaglandins.
对 Lampaya hieronymi Schum. ex Moldenke 的地上部分进行化学研究，得到了齐墩果酸、表齐墩果酸、表马斯里酸、4',7-二甲氧基芹菜素、对羟基苯乙酮和对羟基苯乙酮-β-葡萄糖苷。在寻找潜在抗炎天然产物的过程中，除 4',7-二甲氧基芹菜素外，所有化合物均在体内评估了其抑制急性炎症的能力。我们的研究表明，对羟基苯乙酮和三萜类化合物分别在注射角叉菜胶后的 1 - 3 小时和 3 - 5 小时，对角叉菜胶诱导的小鼠爪肿胀产生了保护作用。这些结果表明，它们的作用可能与组胺、5-羟色胺、激肽和前列腺素的释放有关。
