Hockertz S, Paulini I, Rogalla K, Schettler T
Fraunhofer Institute for Toxicology, Hannover, FRG.
Agents Actions. 1993 Sep;40(1-2):119-23. doi: 10.1007/BF01976760.
The influence of acetylsalicylic acid (ASA, CAS 50-78-2) on the Listeria monocytogenes infection in balb/c mice was investigated. One day prior to lethal or sublethal infection, balb/c mice were treated intravenously with therapeutic concentrations of ASA alone or ASA in combination with murine recombinant interferon gamma, a lymphokine produced by T-helper cells. Three days post-infection, parasite burdens of spleen and liver were determined by the colony-forming unit assay. It was shown that the prophylactic application of ASA in a concentration of 5 mg/kg body weight resulted in a more than 10-fold reduction of viable Listeria monocytogenes in spleen and liver of balb/c mice. In addition, the combination of a suboptimal dosage of interferon gamma with ASA resulted in a significantly higher survival rate compared to the untreated controls.
研究了乙酰水杨酸（ASA，化学物质登记号50-78-2）对balb/c小鼠单核细胞增生李斯特菌感染的影响。在致死性或亚致死性感染前一天，对balb/c小鼠静脉注射治疗浓度的ASA单独用药，或ASA与小鼠重组干扰素γ（一种由辅助性T细胞产生的淋巴因子）联合用药。感染后三天，通过菌落形成单位测定法确定脾脏和肝脏中的寄生虫负荷。结果表明，以5 mg/kg体重的浓度预防性应用ASA可使balb/c小鼠脾脏和肝脏中活的单核细胞增生李斯特菌减少10倍以上。此外，与未治疗的对照组相比，次优剂量的干扰素γ与ASA联合使用可显著提高存活率。
