Venkatasubramanian P N, Shen Y J, Wyrwicz A M
Department of Radiology, University of Illinois at Chicago 60612.
NMR Biomed. 1993 Nov-Dec;6(6):377-82. doi: 10.1002/nbm.1940060605.
19F one-dimensional chemical shift imaging and one-pulse techniques were used to follow the uptake of isoflurane in rabbit brain in vivo. Brain isoflurane appeared mainly in two adjacent slices of cerebral cortex. Both slices showed increase in anesthetic content at similar rates. A biphasic first-order uptake pattern with an initial fast component and a slower rate for the duration of the uptake was observed by the one-pulse technique. Only the slower kinetic was followed by chemical shift imaging due to constraints on temporal resolution. Anesthetic levels in arterial blood reached equilibrium significantly earlier than in brain, suggesting a 'restricted' diffusion into brain tissue for this agent.
采用¹⁹F一维化学位移成像和单脉冲技术在体内追踪兔脑对异氟烷的摄取。脑内异氟烷主要出现在大脑皮层相邻的两片区域。两片区域的麻醉剂含量均以相似速率增加。单脉冲技术观察到一种双相一级摄取模式，初始有快速成分，摄取过程持续阶段速率较慢。由于时间分辨率的限制，化学位移成像仅追踪到较慢的动力学过程。动脉血中的麻醉剂水平比脑内更早达到平衡，这表明该药物向脑组织的扩散是“受限的”。
