Wyrwicz A M, Conboy C B, Ryback K R, Nichols B G, Eisele P
Biochim Biophys Acta. 1987 Jan 19;927(1):86-91. doi: 10.1016/0167-4889(87)90069-3.
The time course of isoflurane elimination from rabbit brain was studied in vivo with 19F-NMR spectroscopy. Two exponential decay functions with different time constants were observed and assigned to two distinct brain compartments. Isoflurane has a 26 min time constant for one compartment (similar to a value of 25 min with halothane) but 174 min in the second one, compared with 320 min for halothane. The shorter half-life for isoflurane may be due to lower solubility of this agent in brain tissue. Comparison of isoflurane 19F chemical shifts in solvents in isolated brain lipids and in whole brain tissue indicates that the anesthetic present in the brain exists in a single environment (on the NMR time scale), which is a weighted average of both hydrophilic and hydrophobic environments.
采用19F核磁共振波谱技术在体内研究了异氟烷从兔脑消除的时程。观察到两个具有不同时间常数的指数衰减函数，并将其归因于两个不同的脑区室。异氟烷在一个区室的时间常数为26分钟（与氟烷的25分钟值相似），但在第二个区室为174分钟，而氟烷为320分钟。异氟烷较短的半衰期可能是由于该药物在脑组织中的溶解度较低。对分离的脑脂质和全脑组织中溶剂中异氟烷19F化学位移的比较表明，脑中存在的麻醉剂处于单一环境（在核磁共振时间尺度上），这是亲水和疏水环境的加权平均值。
