Milanowski J, Dutkiewicz J, Fafrowicz B
Kliniki i Katedry Chorób Płuc i Gruźlicy Akademii Medycznej, Lublinie.
Pneumonol Alergol Pol. 1993;61(11-12):592-7.
The effects of antigen and endotoxin of Erwinia herbicola on physiological status of alveolar macrophages were studied in vitro. The studies comprised determination of the cytotoxicity of antigens + and their effects on superoxide anion and interleukin-1 (IL-1) generation by alveolar macrophages. It was found that tested agents were cytotoxic for alveolar macrophages in large concentrations (from 1000 micrograms/ml. In lower concentrations (1-10 micrograms/ml) they stimulated the activity of alveolar macrophages, causing significant increase in superoxide anion(O2) and IL-1 generation. Superoxide anion and IL-1 production may be of importance in pathogenesis of organic dust-induced lung diseases and our results indicate that agents associated with these diseases induced their production.
体外研究了草生欧文氏菌的抗原和内毒素对肺泡巨噬细胞生理状态的影响。这些研究包括测定抗原的细胞毒性及其对肺泡巨噬细胞超氧阴离子生成和白细胞介素 -1（IL -1）生成的影响。结果发现，受试药物在高浓度（1000微克/毫升起）时对肺泡巨噬细胞具有细胞毒性。在较低浓度（1 - 10微克/毫升）时，它们刺激肺泡巨噬细胞的活性，导致超氧阴离子（O₂）和IL -1生成显著增加。超氧阴离子和IL -1的产生可能在有机粉尘所致肺部疾病的发病机制中具有重要意义，我们的结果表明与这些疾病相关的因素可诱导它们的产生。
