Milanowski J, Dutkiewicz J, Fafrowicz B
Kliniki i Katedry Chorób Płuc i Gruźlicy Akademii Medycznej, Lublinie.
Pneumonol Alergol Pol. 1993;61(11-12):598-605.
The pulmonary response of guinea pigs to inhalation of antigen and endotoxin of Erwinia herbicola was investigated. Pulmonary parameters monitored in this study were breathing rate, cellular differential counts from bronchoalveolar lavage fluid, superoxide anion and interleukin-1 (IL-1) production by alveolar macrophages. Both agents caused an increase in breathing rate; an influx of neutrophils, lymphocytes, and red blood cells to the lung; and an enhancement of secretion of superoxide anions and IL-1 by pulmonary macrophages. The results indicate significant role of extrinsic bacilli Erwinia herbicola in respiratory pathology and show new mechanisms of their action.
研究了豚鼠对草生欧文氏菌抗原和内毒素吸入的肺部反应。本研究监测的肺部参数包括呼吸频率、支气管肺泡灌洗液中的细胞分类计数、肺泡巨噬细胞产生的超氧阴离子和白细胞介素-1（IL-1）。两种制剂均导致呼吸频率增加；中性粒细胞、淋巴细胞和红细胞流入肺部；以及肺部巨噬细胞分泌超氧阴离子和IL-1增加。结果表明草生欧文氏菌这种外源杆菌在呼吸道病理学中具有重要作用，并揭示了其新的作用机制。
