Skórska C, Milanowski J, Dutkiewicz J, Fafrowicz B
Zakładu Aerobiologii i Alergologii, Instytutu Medycyny Wsi w Lublinie.
Pneumonol Alergol Pol. 1996;64 Suppl 1:9-18.
Laboratory animals (guinea pigs and rabbits) were exposed to the inhalation of aerosolized endotoxins derived from the cell mass of Alcaligenes faecalis and Erwinia herbicola, the Gram-negative bacteria commonly occurring in organic dusts. Single 1 hour-lasting exposure caused the significant increase in the number of free lung cell, mostly lymphocytes, compared to the control group exposed to saline (P < 0.001). Prolonged exposure to tested endotoxins (Fifteen 1 hour-lasting exposures every second day) caused both specific and non specific immunological changes: enhanced inhibition of leukocyte migration production of precipitins, and activation of alveolar macrophages, wes assessed by greater antibacterial activity and increased interleukin I (IL-I) production. The results indicate that the endotoxins of examined bacteria represent a potential risk of inflammatory lung reaction and respiratory disease for agricultural workers inhaling organic dusts contaminated with these organisms.
实验动物（豚鼠和兔子）吸入了源自粪产碱菌和草生欧文氏菌细胞团的雾化内毒素，这两种革兰氏阴性菌常见于有机粉尘中。与吸入生理盐水的对照组相比，单次持续1小时的暴露导致游离肺细胞数量显著增加，主要是淋巴细胞（P < 0.001）。长时间暴露于测试的内毒素（每隔一天进行15次每次持续1小时的暴露）导致了特异性和非特异性免疫变化：白细胞迁移抑制增强、沉淀素产生、肺泡巨噬细胞活化，通过更强的抗菌活性和白细胞介素I（IL-I）产生增加来评估。结果表明，所检测细菌的内毒素对吸入被这些生物体污染的有机粉尘的农业工人构成了肺部炎症反应和呼吸系统疾病的潜在风险。
