Munkholm P, Langholz E, Davidsen M, Binder V
Department of Medical Gastroenterology C, Herlev Hospital, University of Coppenhagen, Denmark.
Gut. 1994 Mar;35(3):360-2. doi: 10.1136/gut.35.3.360.
The outcome of the first steroid treatment course was prospectively studied in a regional cohort of 196 patients with Crohn's disease diagnosed 1979-1987. The immediate outcome after 30 days, and the prolonged outcome 30 days after treatment had stopped, are described. In all 109 patients treatment was analysed. Complete remission was obtained in 48%, partial remission in 32%, and no response in 20% within 30 days of treatment. Among primary responders (complete and partial remission), 55% remained in prolonged response after treatment had finished, while 45% relapsed or could not be withdrawn from treatment within one year. Localisation of disease, age, sex or clinical symptoms did not significantly correlate with outcome, which can be summarised as prolonged steroid response in 44%, steroid dependency in 36%, and steroid resistant in 20% of the patients.
对1979年至1987年确诊的196例克罗恩病患者组成的地区队列进行了前瞻性研究，观察首个类固醇治疗疗程的结果。描述了治疗30天后的即时结果以及治疗停止30天后的长期结果。对全部109例患者的治疗情况进行了分析。治疗30天内，48%的患者获得完全缓解，32%的患者获得部分缓解，20%的患者无反应。在初次有反应者（完全缓解和部分缓解）中，治疗结束后55%的患者保持长期缓解，而45%的患者复发或在一年内无法停用治疗。疾病部位、年龄、性别或临床症状与结果无显著相关性，可总结为44%的患者有长期类固醇反应，36%的患者类固醇依赖，20%的患者类固醇抵抗。
