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3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity.

作者信息

Roggo B E, Petersen F, Delmendo R, Jenny H B, Peter H H, Roesel J

机构信息

Biotechnology Research Laboratories, CIBA-GEIGY Limited, Basel, Switzerland.

出版信息

J Antibiot (Tokyo). 1994 Feb;47(2):136-42. doi: 10.7164/antibiotics.47.136.

DOI:10.7164/antibiotics.47.136
PMID:8150707
Abstract

In the course of a screening program for HIV-1 protease inhibiting activity, six new homologues of 3-alkanoyl-5-hydroxymethyl tetronic acids (1 approximately 6) and the known natural product resistomycin (7) were isolated from cultures of the Actinomycete strain DSM 7357. The substituted tetronic acids belong to a recently described structural class of secondary metabolites. The HIV-1 activity of resistomycin (7) has not been reported before.

摘要

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