3-Alkanoyl-5-hydroxymethyl tetronic acid homologues and resistomycin: new inhibitors of HIV-1 protease. I. Fermentation, isolation and biological activity.
作者信息
Roggo B E, Petersen F, Delmendo R, Jenny H B, Peter H H, Roesel J
机构信息
Biotechnology Research Laboratories, CIBA-GEIGY Limited, Basel, Switzerland.
出版信息
J Antibiot (Tokyo). 1994 Feb;47(2):136-42. doi: 10.7164/antibiotics.47.136.
PMID:8150707
Abstract
In the course of a screening program for HIV-1 protease inhibiting activity, six new homologues of 3-alkanoyl-5-hydroxymethyl tetronic acids (1 approximately 6) and the known natural product resistomycin (7) were isolated from cultures of the Actinomycete strain DSM 7357. The substituted tetronic acids belong to a recently described structural class of secondary metabolites. The HIV-1 activity of resistomycin (7) has not been reported before.
摘要
Zotero 插件