Wang D W, Zhao H Y
Cardiology Department, Tongji Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1993;13(4):193-8. doi: 10.1007/BF02888007.
In order to search for effective drugs to reduce restenosis incidence after coronary angioplasty, we studied the effects of a Chinese herb, extract of Andrographis Paniculata Nees (APN), and Fish Oil (FO) on atherosclerotic stenosis and restenosis after experimental angioplasty. Preliminary results showed that APN can significantly alleviate atherosclerotic iliac artery stenosis induced by both deendothelialization and high cholesterol diet (control group, stenosis incidence 100%, stenotic severe degree 60.53 +/- 31.03%, of which 30% arteries (6) are total occlusion; FO group: stenotic incidence and severe degree are 77% and 53.00 +/- 21.17%, respectively, and in APN group they are 70% and 25.39 +/- 10.52%, respectively, P < 0.01), and follow-up angiography 4 weeks after angioplasty showed that dilated iliac arteries in control group all had severe restenosis, but in APN group no or only mild restenosis occurs, and in FO group restenosis is as severe as stenotic degree prior to angioplasty. These preliminary results suggest that APN and FO can significantly alleviate stenosis induced by deendothelialization and high cholesterol diet and restenosis after angioplasty, while the former has a more marked effect. The above findings lead the authors to conclude that APN may play an important role in preventing restenosis after coronary angioplasty, but FO may be useful in reducing the extent of of restenosis after coronary angioplasty.
为了寻找降低冠状动脉成形术后再狭窄发生率的有效药物，我们研究了一种中药穿心莲提取物（APN）和鱼油（FO）对实验性血管成形术后动脉粥样硬化狭窄和再狭窄的影响。初步结果显示，APN能显著减轻去内皮化和高胆固醇饮食诱导的髂动脉粥样硬化狭窄（对照组狭窄发生率100%，狭窄严重程度60.53±31.03%，其中30%的动脉（6条）完全闭塞；FO组：狭窄发生率和严重程度分别为77%和53.00±21.17%，APN组分别为70%和25.39±10.52%，P<0.01），血管成形术后4周的随访血管造影显示，对照组扩张的髂动脉均有严重再狭窄，而APN组无再狭窄或仅有轻度再狭窄，FO组再狭窄程度与血管成形术前的狭窄程度相同。这些初步结果表明，APN和FO能显著减轻去内皮化和高胆固醇饮食诱导的狭窄以及血管成形术后的再狭窄，而前者作用更显著。上述发现使作者得出结论，APN可能在预防冠状动脉成形术后再狭窄中起重要作用，而FO可能有助于减轻冠状动脉成形术后再狭窄的程度。
