衰老与来自脑皮质切片的替尤斯毒素所引发的乙酰胆碱释放
Ageing and acetylcholine release by tityustoxin from brain cortical slices.
作者信息
Queiroz I B, Turchetti-Maia R M, Moraes-Santos T, Gomez M V
机构信息
Departamento de Farmacologia, Faculdade, de Farmácia, Instituto de Ciências Biológicas-UFMG, Belo Horizonte, Brazil.
出版信息
Toxicon. 1994 Feb;32(2):232-4. doi: 10.1016/0041-0101(94)90113-9.
PMID:8153963
Abstract
The ability of tityustoxin to trigger acetylcholine release was studied in cerebral cortical slices from 2, 12 and 23-month-old rats. The effect of tityustoxin to induce the release of acetylcholine was reduced by 60% in senescent animals. This result suggests that ageing reduces the sensitivity of cerebral cortical nerve terminals to tityustoxin.
摘要
在2月龄、12月龄和23月龄大鼠的大脑皮层切片中研究了毒蛛毒素触发乙酰胆碱释放的能力。在衰老动物中，毒蛛毒素诱导乙酰胆碱释放的作用降低了60%。这一结果表明，衰老降低了大脑皮层神经末梢对毒蛛毒素的敏感性。
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