Gomez M V, Farrell N
Neuropharmacology. 1985 Nov;24(11):1103-7. doi: 10.1016/0028-3908(85)90198-4.
The effect of tityustoxin and ruthenium red on the release of acetylcholine from slices of cortex from the brain of the rat was studied. The results showed that ruthenium red stimulated the elicited release of acetylcholine (ACh) by tityustoxin. The effect was dependent on the incubation time and the concentration of ruthenium red. The stimulation was dependent on calcium and was blocked by the presence of tetrodotoxin and ethyleneglycol-bis(beta aminoethyl ether)N,N'-tetraacetic acid (EGTA). It is suggested that the inhibition of buffering by calcium in mitochondria, by ruthenium red increased the level of ionized calcium in the symaptoplasm, causing an increase in the release of acetylcholine.
研究了巴西游走蛛毒素和钌红对大鼠大脑皮层切片乙酰胆碱释放的影响。结果表明，钌红刺激了巴西游走蛛毒素引发的乙酰胆碱（ACh）释放。该效应取决于孵育时间和钌红浓度。这种刺激依赖于钙，并被河豚毒素和乙二醇双（β-氨基乙基醚）N，N'-四乙酸（EGTA）的存在所阻断。有人认为，钌红通过抑制线粒体中钙的缓冲作用，增加了突触质中离子钙的水平，从而导致乙酰胆碱释放增加。
