Marty P, Le Fichoux Y, Pratlong F, Gari-Toussaint M
Faculté de Médecine, Université de Nice-Sophia Antipolis, France.
Trans R Soc Trop Med Hyg. 1994 Jan-Feb;88(1):33-4. doi: 10.1016/0035-9203(94)90485-5.
In 8 years (1985-1992), 65 cases of human visceral leishmaniasis (HVL) have been diagnosed in the department of Alpes-Maritimes, France, 56 of them having been infected locally. The annual frequency has increased from 3 cases in 1985 to 15 cases in 1992. There is a low rate of paediatric cases (29%) and a predominance of males among adult cases (85%). Since 1986, 19 cases of co-infection with Leishmania and human immunodeficiency virus 1 have been reported, corresponding to 40% of adult cases and to 30% of the total cases. The frequency of co-infections is stable at about 3 per annum. Isoenzymatic identification of the strains isolated from patients confirmed Leishmania infantum zymodeme MON-1 as responsible for most if not all HVL in the department of Alpes-Maritimes; 42 of the 44 strains isolated belonged to that zymodeme.
在8年时间里（1985年至1992年），法国滨海阿尔卑斯省确诊了65例人体内脏利什曼病（HVL），其中56例为本地感染。年发病率从1985年的3例增加到了1992年的15例。儿科病例比例较低（29%），成年病例中男性占主导（85%）。自1986年以来，已报告19例利什曼原虫与人类免疫缺陷病毒1合并感染病例，占成年病例的40%，占总病例的30%。合并感染的频率稳定在每年约3例。对从患者身上分离出的菌株进行同工酶鉴定证实，婴儿利什曼原虫酶谱型MON-1是滨海阿尔卑斯省大部分（如果不是全部）人体内脏利什曼病的病原体；分离出的44株菌株中有42株属于该酶谱型。
