Sabbah A, Kerdranvat H, Lauret M G
Laboratoire d'Immuno-allergologie, CHU, Angers, France.
Allerg Immunol (Paris). 1993 Dec;25(10):408-10, 413-5.
The recent contributions to the mechanisms of regulation of IgE by cytokines has produced development of kits that are usable in IFN gamma in atopic dermatitis where we have fixed a significant basal level in contrast to a reference group, though there is no possibility of making a modification in asthma. However, this seems to us to be logical since this change of IFN gamma was studied in peripheral blood when the study should be made of broncho-alveolar lavage in asthma. The assay kits for IL4 lack performance and "realism" in their threshold level of detection. This study has also given comparison of the variation of the two cytokines in comparison with total and specific IgE.
近期有关细胞因子对IgE调节机制的研究成果催生了一些检测试剂盒,这些试剂盒可用于检测特应性皮炎患者体内的γ干扰素(IFNγ)。与参照组相比,我们发现特应性皮炎患者体内γ干扰素的基础水平显著升高。然而,目前尚无法将这些试剂盒用于哮喘检测。不过,在我们看来这是合乎逻辑的,因为针对γ干扰素变化的研究是基于外周血进行的,而对于哮喘的研究应该针对支气管肺泡灌洗样本。白细胞介素4(IL4)检测试剂盒在检测阈值水平方面缺乏性能和“真实性”。本研究还对这两种细胞因子与总IgE和特异性IgE的变化进行了比较。