Kisters K, Spieker C, Tepel M, Zidek W
Medizinische Universitäts Poliklinik, Münster, Germany.
Magnes Res. 1993 Dec;6(4):355-60.
In the present study the effect of oral physiological magnesium supplementation on atherogenic risk factors such as serum lipids and blood pressure was examined. Sixty-nine patients with hyperlipidaemia of Frederickson types IV and IIb were investigated with regard to renal function, blood pressure, serum cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol, and plasma and erythrocytic magnesium concentrations. All patients were on cholesterol-poor (< 90 mg cholesterol/d) and energy-restricted diet (< 1200 kcal/d). Thirty-seven patients received 500 mg magnesium (oral) daily as a supplement. All measurements were performed before and four weeks after starting treatment. The results of our study show that oral physiological magnesium supplementation in addition to the usual dietary measures can be beneficial with regard to serum triglycerides (values, means +/- SD, decreased from 198.17 +/- 47.01 to 163.20 +/- 40.55 mg/dl, P < 0.05), but exerts no positive effect on blood pressure or serum cholesterol. Furthermore, erythrocyte magnesium concentration increased significantly during oral physiological magnesium supplementation (values, means +/- SD, increased from 1.72 +/- 0.22 to 1.91 +/- 0.18 mmol/litre, P < 0.05), whereas plasma magnesium concentrations did not change significantly.
在本研究中，研究了口服生理剂量镁补充剂对血清脂质和血压等动脉粥样硬化危险因素的影响。对69例弗雷德里克森IV型和IIb型高脂血症患者进行了肾功能、血压、血清胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇以及血浆和红细胞镁浓度的研究。所有患者均采用低胆固醇（<90毫克胆固醇/天）和能量限制饮食（<1200千卡/天）。37例患者每天口服补充500毫克镁。所有测量均在开始治疗前和治疗四周后进行。我们的研究结果表明，除常规饮食措施外，口服生理剂量镁补充剂对血清甘油三酯有益（数值，均值±标准差，从198.17±47.01降至163.20±40.55毫克/分升，P<0.05），但对血压或血清胆固醇没有积极影响。此外，口服生理剂量镁补充剂期间红细胞镁浓度显著升高（数值，均值±标准差，从1.72±0.22升至1.91±0.18毫摩尔/升，P<0.05），而血浆镁浓度没有显著变化。
